Pleiotrophin growth factor receptor for the treatment of...

Details Pleiotrophin growth factor receptor for the treatment of... Pleiotrophin growth factor receptor for the treatment of...

C - Chemistry, Metallurgy

07

K

C07K 14/475 (2006.01) A61K 38/18 (2006.01) C07K 16/22 (2006.01) C12N 5/16 (2006.01) C12N 15/18 (2006.01) A61K 39/00 (2006.01) C07K 14/71 (2006.01)

Patent

CA 2736957

This invention relates to the discovery that pleiotrophin binds to and activates a pleiotrophin-receptor which is responsible for the events associated with pleiotrophin activity including tumorigenesis, cell proliferation, and cell invasion. By interfering with that association, the cascade of events associated with pleiotrophin activity can be prevented or reversed. Further, by evaluating the effect of different compounds and conditions on the interaction, new drugs and treatments can be identified for use in preventing certain cancers and growth and developmental disorders.

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