Pliable biological graft materials and their methods of...

A - Human Necessities – 61 – F

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A61F 2/06 (2006.01) A61L 27/00 (2006.01) A61L 27/24 (2006.01) A61F 2/00 (2006.01)

Patent

CA 2101557

-50- PLIABLE BIOLOGICAL VASCULAR GRAFTS AND THEIR METHODS OF MANUFACTURE Abstract Preparing chemically cross-linked collagenous biological graft material (10a) by preparation processes which include the step of altering the locations and/or orientations of chemical cross-linkages formed during the collagen cross-linking process. Embodiments of the method include various processes whereby physical force, stress or movement is applied to alter the relative positioning of the collagen fibers within the graft materials (10a) during at least the initial period of exposure to the collagen cross-linking reagent.

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