Plks as modifiers of the beta catenin pathway and methods of...

Details Plks as modifiers of the beta catenin pathway and methods of... Plks as modifiers of the beta catenin pathway and methods of...

G - Physics

01

N

G01N 33/53 (2006.01)

Patent

CA 2546771

Human PLK genes are identified as modulators of the beta catenin pathway, and thus are therapeutic targets for disorders associated with defective beta catenin function. Methods for identifying modulators of beta catenin, comprising screening for agents that modulate the activity of PLK are provided.

L'invention concerne des gènes PLK humains identifiés comme modulateurs de la voie de la bêta-caténine, et, par conséquent, utiles comme cibles thérapeutiques pour des affections associées à une fonction de bêta-caténine déficiente. L'invention concerne également des méthodes destinées à identifier des modulateurs de la bêta-caténine et consistant à cribler des agents modulant l'activité PLK.

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