Podocalyxin like sialomucins having selectin ligand activity

Details Podocalyxin like sialomucins having selectin ligand activity Podocalyxin like sialomucins having selectin ligand activity

C - Chemistry, Metallurgy

12

N

C12N 15/00 (2006.01) C07K 14/435 (2006.01) C07K 14/705 (2006.01) C07K 16/00 (2006.01) C07K 16/28 (2006.01) C12N 15/63 (2006.01) C12P 21/00 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2318068

Podocalyxin like proteins (e.g. PCLP and PCLP-2) having selectin ligand activity are provided. Also provided are nucleic acid compositions encoding novel PCLP-2 proteins. The subject polypeptide and nucleic acid compositions find use in a variety of applications, including research, diagnostic, and therapeutic agent screening applications, as well as in treatment therapies for disease conditions associated with podocalyxin like protein activity. In particular, methods of treating diseases associated with podocalyxin like protein selectin binding activity and/or chemokine presenting activity are provided, where such diseases include inflammation and the like.

L'invention porte sur des protéines de type podocalyxines telles que PCLP et PCLP-2) qui ont une activité de ligand de sélectine. L'invention porte également sur des compositions d'acide nucléique codant les nouvelles protéines PCLP-2. Les compositions de polypeptides et d'acide nucléique de l'invention s'avèrent être utiles dans une variété d'applications telles que des applications de recherche, de diagnostic et de test d'agents thérapeutiques, ainsi que dans des traitements thérapeutiques d'états pathologiques associés à l'activité des protéines de type podocalyxines. L'invention porte notamment sur des procédés de traitement de maladies associées à l'activité de liaison de la sélectine des protéines de type podocalyxines et/ou à l'activité de présentation de la chémokine, ces maladies comprenant les inflammations et leurs analogues.

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