Polar-modified bonded phase materials for chromatographic...

Details Polar-modified bonded phase materials for chromatographic... Polar-modified bonded phase materials for chromatographic...

B - Operations, Transporting

01

J

B01J 20/22 (2006.01) B01D 15/08 (2006.01) B01J 20/32 (2006.01)

Patent

CA 2554650

Novel compositions are disclosed for use as a stationary phase in chromatography comprising an inorganic substrate that is modified with at least one silane having the formula R1 .delta.-Q.alpha.-(CH2) .beta.SiR2.gamma.X3-.gamma.. In a preferred embodiment, the inorganic substrate is silica gel and is modified with at least two silanes. Methods of preparation and use in chromatographic applications are disclosed. The novel compositions provide superior chromatographic performance, reduced silanol activity, enhanced stability, and reproducibility in preparation and performance.

L'invention concerne des nouvelles compositions à utiliser en tant que phase stationnaire en chromatographie, qui comprennent un substrat inorganique modifié par au moins un silane de formule suivante : R?1¿¿.delta.? -Q¿.alpha.?-(CH¿2?) ¿.beta.?SiR?2¿¿??X¿3-?.? Dans un mode de réalisation préféré, ledit substrat inorganique est un gel de silice et est modifié par au moins deux silanes. L'invention concerne également des méthodes de préparation et d'utilisation desdites compositions dans des applications chromatographiques. Lesdites nouvelles compositions permettent d'obtenir une performance chromatographique supérieure, une activité silanol réduite, une stabilité améliorée, et une reproductibilité en ce qui concerne leur préparation et leur performance.

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