Polar quinazolines as liver x receptors ( lxrs ) modulators

Details Polar quinazolines as liver x receptors ( lxrs ) modulators Polar quinazolines as liver x receptors ( lxrs ) modulators

C - Chemistry, Metallurgy

07

D

C07D 239/72 (2006.01) A61K 31/517 (2006.01) A61P 3/00 (2006.01) A61P 9/10 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2742023

Disclosed are polar quinazoline-based modulators of Liver X receptors (LXRs) and related methods. The modulators include compounds of formula (I): INSERT FORMULA HERE AS IT APPEARS IN WRITTEN FORM IN THE SPECIFICATION (I) in which, R1, R2, R3, R4, R5, R6, R22, R23, R24, R25, R26, R27, R28, R29, W, W1, W2, Ra, Rb, Rc, Rd, Re, Rf, Rg, Rh, Ri, Rj, Rm, Rn, Ro, Rp, Rq, Rr, Rs, Rt, Ru, and n can be as defined anywhere herein. In general, these compounds can be used for treating or preventing one or more diseases, disorders, conditions or symptoms mediated by LXRs.

La présente invention concerne des modulateurs des récepteurs hépatiques X (LXR) basés sur des quinazolines polaires et les méthodes correspondantes. Les modulateurs incluent les composés de formule (I) : INSÉRER ICI LA FORMULE TELLE QU'ELLE APPARAÎT SOUS FORME ÉCRITE DANS LA DESCRIPTION (I) où R1, R2, R3, R4, R5, R6, R22, R23, R24, R25, R26, R27, R28, R29, W, W1, W2, Ra, Rb, Rc, Rd, Re, Rf, Rg, Rh, Ri, Rj, Rm, Rn, Ro, Rp, Rq, Rr, Rs, Rt, Ru et n peuvent être tels que définis à un quelconque endroit de l'invention. De façon générale, ce composé peut être employé dans le traitement prophylactique ou thérapeutique d'un ou de plusieurs pathologies, troubles, états pathologiques ou symptômes faisant intervenir les LXR.

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