C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/10 (2006.01) A61K 47/48 (2006.01) C07K 17/00 (2006.01) C12N 15/54 (2006.01) C12Q 1/48 (2006.01) G01N 33/535 (2006.01) G01N 33/566 (2006.01)
Patent
CA 2373918
The present invention relates to binding pockets of a polo domain. In particular, the invention relates to a crystal comprising a binding pocket of a polo domain. The crystal may be useful for modeling and/or synthesizing mimetics of a binding pocket or ligands that associate with the binding pocket. Such mimetics or ligands may be capable of acting as modulators of polo family kinases, and they may be useful for treating, inhibiting, or preventing diseases modulated by such kinases.
Dennis Jim
Hudson John
Kozarova Anna
Leung Genie Chung Chi
Sicheri Frank
Bereskin & Parr
Mount Sinai Hospital
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