Polo-like kinase inhibitors

Details Polo-like kinase inhibitors Polo-like kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/551 (2006.01)

Patent

CA 2700295

The present invention relates generally to processes of making 4-(9- cyclopentyl-7,7-difluoro-5- methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-ylamino)-3- methoxy-N-(1-methylpiperidin-4-yl benzamide and Form A of 4-(9-cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9- tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin -2-ylamino)-3-methoxy-N-(1-methylpiperidin-4-yl benzamide.

La présente invention concerne de manière générale des procédés de fabrication du 4-(9-cyclopentyl-7,7-difluoro-5-méthyl-6-oxo-6,7,8,9-tétrahydro-5H-pyrimido[4,5-b][1,4]diazépin-2-ylamino)-3-méthoxy-N-(1-méthylpipéridin-4-yl benzamide et de la forme A du 4-(9-cyclopentyl-7,7-difluoro-5-méthyl-6-oxo-6,7,8,9-tétrahydro-5H-pyrimido[4,5-b][1,4]diazépin-2-ylamino)-3-méthoxy-N-(1-méthylpipéridin-4-yl benzamide.

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