Poly (adp-ribose) polymerase (parp) inhibitors

Details Poly (adp-ribose) polymerase (parp) inhibitors Poly (adp-ribose) polymerase (parp) inhibitors

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/4985 (2006.01) A61K 31/5365 (2006.01) A61K 31/542 (2006.01) A61P 9/00 (2006.01) A61P 25/00 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) C07D 471/14 (2006.01) C07D 498/14 (2006.01) C07D 513/14 (2006.01)

Patent

CA 2750106

Disclosed are compounds of the following formula: (I) in which R1, R2, R3, R4, R5, R6, R7, X, and t are defined in the specification. Also disclosed are pharmaceutical compositions, kits, and articles of manufacture, which contain the com-pounds, methods and intermediates useful for making the compounds, and methods of using the compounds to treat diseases, dis-orders, and conditions related to PARP activity.

La présente invention concerne des composés de formule (I) suivante dans laquelle R1, R2, R3, R4, R5, R6, R7, X et t sont tels que définis dans le mémoire descriptif. L'invention concerne également des compositions pharmaceutiques, des nécessaires et des articles manufacturés impliquant les composés, les procédés et les intermédiaires utilisables pour la fabrication desdits composés, ainsi que des procédés d'utilisation desdits composés en vue du traitement de maladies, d'affections et de troubles associés à l'activité de la PARP.

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