Poly-amino acidic oligonucleotide-carrier

A - Human Necessities – 61 – K

Patent

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Details

A61K 47/34 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) C12N 15/87 (2006.01)

Patent

CA 2172974

The present invention provides a poly-amino acidic oligonucleotide-carrier comprising a poly-lysine:serine random copolymer. This carrier is bonded with oligonucleotide without causing precipitation, and smoothly releases the bonded oligonucleotide within cells. It is therefore useful as an in vivo transport carrier of an oligonucleotide drug against various genetic diseases and viral diseases such as AIDS. It also makes a great contribution to creation of various useful animals and plants by genetic engineering technique, including virus-resistant plants.

Excipient constitué d'acides polyaminés pour oligonucléotide, comprenant un copolymère statistique poly(lysine-sérine). Cet excipient se combine avec un oligonucléotide sans entraîner de précipitation et libère doucement, dans une cellule, l'oligonucléotide combiné. Pour cette raison, cet excipient peut être utilisé pour l'apport in vivo d'un médicament, en thérapie génique par oligonucléotide, pour le traitement de différents types de génopathies et de maladies virales telles que le SIDA. En outre, cet excipient peut jouer un rôle important dans la création de différentes espèces utiles d'animaux et de plantes telles que des plantes résistant aux virus, par les techniques de génie génétique.

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