Poly-beta-1-->4-n-acetylglucosamine

Details Poly-beta-1-->4-n-acetylglucosamine Poly-beta-1-->4-n-acetylglucosamine

C - Chemistry, Metallurgy

12

P

C12P 19/26 (2006.01) A61K 9/20 (2006.01) A61K 47/48 (2006.01) A61L 31/04 (2006.01) C08B 37/08 (2006.01)

Patent

CA 2177823

A method of producing and purifying poly-.beta.-14-N-acetylglucosamine(p- GlcNAc)polysaccharide species and their derivatives is described. The polysaccharides produced by this method are free of proteins, and substantially free of single amino acids, and other organic and inorganic contaminants. These p-GlcNAc polysaccharides may be used commercially by the biomedical, pharmaceutical, and cosmetic industries in slow drug delivery systems, cell encapsulation systems, and treatments for the prevention of post- surgical adhesions. The figure shows the chemical structure of 100 % p-GlcNAc, wherein "n" is an integer from about 4,000 to about 150,000.

Procédé de production et de purification d'espèces polysaccharidiques de poly-.beta.-1?4-N-acétylglucosamine (p-GlcNAc) ainsi que de leurs dérivés. Les polysaccharides obtenus selon ce procédé sont dépourvus de protéine et pratiquement dépourvus d'aminoacide simple ainsi que d'autres contaminants organiques et inorganiques. Ces polysaccharides de p-GlcNAc se prêtent à une utilisation à l'échelle industrielle par les industries biomédicale, pharmaceutique et cosmétique dans des systèmes d'apport lent de médicaments, des systèmes d'encapsulation cellulaire et des traitements préventifs pour les adhésions post-chirurgicales. La figure illustre la structure chimique de p-GlcNAc, "n" représentant un entier compris entre environ 4000 et 150000.

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