Poly(ethylene glycol) derivatives with proximal reactive groups

Details Poly(ethylene glycol) derivatives with proximal reactive groups Poly(ethylene glycol) derivatives with proximal reactive groups

C - Chemistry, Metallurgy

08

G

C08G 65/333 (2006.01) A61K 47/48 (2006.01) C08G 65/32 (2006.01) C08G 65/329 (2006.01)

Patent

CA 2323048

An activated, substantially water-soluble poly(ethylene glycol) is provided having a linear or branched poly(ethylene glycol) backbone and at least one terminus linked to the backbone through a hydrolytically stable linkage, wherein the terminus is branched and has proximal reactive groups. The free reactive groups are capable of reacting with active moieties in a biologically active agent such as a protein or peptide thus forming conjugates between the activated poly(ethylene glycol) and the biologically active agent.

L'invention concerne un poly(éthylène glycol) activé sensiblement hydrosoluble, présentant un squelette de poly(éthylène glycol) linéaire ou ramifié et au moins une terminaison liée à ce squelette par l'intermédiaire d'un chaînon à stabilité hydrolytique, cette terminaison étant ramifiée et présentant des groupes réactifs proximaux. Les groupes réactifs libres sont capables de réagir avec des fragments actifs dans un agent biologiquement actif, par exemple une protéine ou un peptide, formant ainsi des conjugués entre ledit poly(éthylène glycol) activé et ledit agent biologiquement actif.

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