C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/32 (2006.01) A61K 39/07 (2006.01) A61P 31/04 (2006.01) C07K 16/12 (2006.01)
Patent
CA 2528067
Immunogenic compositions and methods for eliciting an immune response against B. anthracis and other bacilli are provided that include immunogenic conjugates of a poly-.gamma.-glutamic acid (.gamma.PGA) polypeptides of B. anthracis, or of another Bacillus that expresses a .gamma.PGA polypeptide. The .gamma.PGA conjugates elicit an effective immune response against B. anthracis, or against another Bacillus, in mammalian hosts to which the conjugates are administered. The preferred conjugate consists of .gamma.-D-PGA and Bacillus protective antigen.
La présente invention concerne des compositions immunogènes et des procédés permettant de solliciter une réponse immunitaire dirigée contre B. anthracis, et d'autres bacilles. Il s'agit essentiellement de conjugués immunogènes de polypeptides d'un acide poly-.gamma.-glutamique (.gamma.PGA) de B. anthracis ou d'un autre bacille qui exprime un polypeptide (.gamma.PGA). En l'occurrence, ces conjugués de .gamma.PGA sollicitent une réponse immunitaire effective dirigée contre B. anthracis, ou d'autres bacilles, chez des hôtes mammifères auxquels ces conjugués sont administrés. Le conjugué préféré est fait de .gamma.-D-PGA et d'antigène protégeant contre les bacilles.
Kubler-Kielb Joanna
Leppla Stephen
Liu Darrell
Majadly Fathy
Robbins John B.
Department Of Health And Human Services The Government Of The United States Of America Represented By Th
Smart & Biggar
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