C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/12 (2006.01) A61K 39/085 (2006.01)
Patent
CA 2567748
The present invention relates to peptides, particularly human monoclonal antibodies, that bind specifically to poly-N-acetyl glucosamine (PNAG), such as Staphylococcal PNAG, in acetylated, partially acetylated and/or fully deacetylated form. The invention further provides methods for using these peptides in the diagnosis, prophylaxis and therapy of infections by bacteria that express PNAG such as but not limited to Staphylococci and E. coli. Some antibodies of the invention enhance opsonophagocytic killing and in vivo protection against bacteria that express PNAG such as but not limited to Staphylococci and E. coli. Compositions of these peptides, including pharmaceutical compositions, are also provided, as are functionally equivalent variants of such peptides.
L'invention concerne des peptides, en particulier des anticorps monoclonaux humains, qui se lient spécifiquement au poly-N-acétyl glucosamine (PNAG), par exemple le PNAG staphylococcique, sous forme acétylée, partiellement acétylée et/ou totalement déacétylée. L'invention concerne en outre des procédés d'utilisation de ces peptides dans le diagnostic, la prophylaxie et la thérapie d'infections par des bactéries qui expriment PNAG, notamment des staphylocoques et E. coli. Certains anticorps selon l'invention renforcent l'élimination opsonophagocytaire et la protection in vivo contre des bactéries qui expriment le PNAG telles que, notamment, les staphylocoques et E. coli. L'invention concerne enfin des compositions de ces peptides, y compris des compositions pharmaceutiques, ainsi que des variants d'équivalence fonctionnelle de ces peptides.
Cavacini Lisa
Kelly-Quintos Casie Anne
Pier Gerald B.
Posner Marshall R.
Beth Israel Deaconess Medical Center Inc.
Smart & Biggar
The Brigham And Women's Hospital Inc.
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