C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/87 (2006.01) A61K 9/127 (2006.01) A61K 31/70 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) C12N 15/88 (2006.01)
Patent
CA 2202928
The present invention relates to a synthetic transfection system comprising as a carrier a cationic, water soluble or water dispersible polyphosphazene. In addition, it relates to a method for introducing DNA fragments in target cells, comprising contacting these DNA fragments with a polyphosphazene which is at least partially substituted with cationic substituents and subsequently contacting the obtained transfection system wits target cells. Finally, the invention involves the use of a polyphosphazene which is at least partially substituted with cationic substituents as transfection vehicle.
Cette invention a trait à un système de transfection de synthèse comportant un polyphosphazène cationique hydrosoluble ou hydrodispersible comme support. Elle porte, de surcroît, sur un procédé permettant d'introduire des fragments d'ADN dans des cellules cibles, consistant à mettre ces fragments d'ADN en contact avec un polyphosphazène, au moins partiellement substitué par des substituants cationiques, et à mettre ensuite en contact le système de transfection ainsi obtenu avec des cellules cibles. Cette invention concerne, en dernier lieu, l'utilisation d'un polyphosphazène, au moins partiellement substitué par des substituants cationique, comme véhicule de transfection.
Bout Abraham
Hennink Wilhelmus Everhardus
Borden Ladner Gervais Llp
Crucell Holland B.v.
Introgene B.v.
Ocotplus B.v.
Universiteit Utrecht
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