Poly(potassium and sodium styrene sulfonate), its...

C - Chemistry – Metallurgy – 08 – F

Patent

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C08F 212/14 (2006.01) A61K 31/74 (2006.01) A61K 31/795 (2006.01) A61P 1/12 (2006.01) C08F 12/30 (2006.01)

Patent

CA 2492211

Antibiotic-associated diarrhea, such as that caused by Clostridium difficile, represents a serious medical complication that can result from administering a broad~spectrum antibiotic to a subject. Such diarrhea leads to significant potassium loss from the subject. The present invention discloses a polymeric therapeutic agent that treats antibiotic-associated diarrhea and is physiologically potassium neutral. This polymer contains polystyrene sodium sulfonate and polystyrene potassium sulfonate repeat units.

Une diarrhée associée aux antibiotique, telle que celle provoquée par Clostridium difficile, représente une complication médicale sérieuse qui peut résulter de l'administration d'un antibiotique à large spectre chez un sujet. Une telle diarrhée conduit à une perte significative de potassium chez le sujet. L'invention concerne un agent thérapeutique polymère qui traite une diarrhée associée aux antibiotiques et qui est physiologiquement neutre en potassium. Ledit polymère contient du sulfonate polystyrènique de sodium et des unités de répétition de sulfonate polystyrènique de potassium.

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