Poly-tlr antagonist

Details Poly-tlr antagonist Poly-tlr antagonist

A - Human Necessities

61

K

A61K 35/74 (2006.01)

Patent

CA 2670124

Mycobacterium w or its components are found to have poly TLR antagonistic activity to induced TLRs by varieties of TLR ligands. The induced TLR against which inhibitory effect is seen includes TLR 3, 4, 5, 6, 7, 8, 9. They also display antagonistic activities to effects of TLR ligands. They are also useful in management of diseases wherein TLRs are over expressed, like sepsis, multiple sclerosis, optic neuritis, Chronic obstructive pulmonary diseases multiple myeloma etc.

Il a été découvert que la mycobactérie w ou ses composants possèdent une activité antagoniste de poly-TLR, contre les TLS induits par des variétés de ligands des TLR. Les TLR induits contre lesquels un effet inhibiteur est observé comprennent les TLR 3, 4, 5, 6, 7, 8, 9. Ces mycobactéries ou composants présentent également une activité antagoniste contre les effets des ligands des TLR. Ils sont en outre utiles pour le traitement des maladies dans lesquelles les TLR sont surexprimés, telles que la sepsie, la sclérose en plaques, la névrite optique, la maladie pulmonaire obstructive chronique, le myélome multiple, etc.

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