G - Physics – 01 – N
Patent
G - Physics
01
N
150/7
G01N 33/84 (2006.01) C08F 8/12 (2006.01) G01N 21/80 (2006.01)
Patent
CA 1336254
Polyacrylamide gels containing bound dye indicator molecules being sensitive to pH variation are treated with an aqueous solution for a period of time until the shifting of the pK value of the gel, due to the treatment, has finished. Gels embodying the present invention allow an exact pH measurement over a period of several days and can be used, for example for pH measurements in a human body during a surgical operation and several days thereafter. The gels are made by combining a dye indicator and a polymerizable acrylamide. The resulting polyacrylamide gel has a number of reactive groups that are subject to hydrolysis during the use of the gel. This hydrolysis causes undesired intramolecular side reactions between the gel and the dye indicator that cause a shift in the pK value of the gel over time, which shift diminishes the accuracy of the gel as a pH indicator. A chemical binding agent is bound to the reactive groups to prevent their hydrolysis and to prevent the aforementioned intramolecular side reactions from occurring. The binding agent may be an alpha-amino carboxylic acid.
596062
Rupp Lothar
Wunderling Martin
Hewlett-Packard Company
Sim & Mcburney
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