C - Chemistry – Metallurgy – 08 – L
Patent
C - Chemistry, Metallurgy
08
L
C08L 71/02 (2006.01) A61L 24/00 (2006.01) A61L 24/04 (2006.01) A61L 27/26 (2006.01) A61L 27/34 (2006.01) A61L 31/04 (2006.01) C08L 5/08 (2006.01)
Patent
CA 2430130
Hyaluronic acid and polyalkylene glycol (PAG) based materials have been found to exhibit a synergistic interaction, in which the viscosity of the mixture is more than twice as high as the viscosity expected from the viscosity of the individual components. The mixture otherwise has similar properties to those of its constituents, and in particular will crosslink to form covalently crosslinked gels if the PEG carries crosslinkable groups. The viscous formulation adheres well to tissue, and has applications as a tissue sealant and in tissue coating, prevention of adhesions, cell immobilization, regeneration of cartilage, bone and other tissue, as well as in controlled delivery of hyaluronic acid to sites in the body. Related materials exhibit similar effects.
L'invention concerne des matières à base d'acide hyaluronique et de polyalkylène glycol (PAG) présentant une interaction synergique, dans lesquelles la viscosité du mélange est supérieure à deux fois la viscosité escomptée des composants individuels. Le mélange présente autrement des propriétés similaires à celles de ses constituants et, notamment une réticulation permettant de former par covalence des gels réticulés, si le PEG porte des groupes réticulables. La formulation visqueuse adhère bien aux tissus et peut être appliquée comme scellant de tissus et revêtement de tissus, dans la prévention de l'adhérence, dans l'immobilisation cellulaire, dans la régénération du cartilage, des os et d'autres tissus, ainsi que dans l'administration régulée d'acide hyaluronique à des sites dans le corps. L'invention concerne également des matières relatives présentant les mêmes effets.
Avila Luis Z.
Jarrett Peter K.
Kramer Hildegard M.
Philbrook Michael C.
Focal Inc.
Genzyme Corporation
Smart & Biggar
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