Polyamide chains of precise length, methods to manufacture...

Details Polyamide chains of precise length, methods to manufacture... Polyamide chains of precise length, methods to manufacture...

C - Chemistry, Metallurgy

08

G

C08G 69/10 (2006.01) C07K 1/107 (2006.01) C08G 69/00 (2006.01) C08G 69/06 (2006.01)

Patent

CA 2351739

Provided are chains of precise length and methods for their preparation. These chains are formed by the reaction of a derivative of a diacid and a diamine in a stepwise manner on a support. One of the reactants contains a water soluble oligomer, preferably polyethylene glycol. These chains are then used to chemically modify target macromolecules such as biologically important polypeptides.

La présente invention concerne des chaînes de longueur précise et leur procédé d'élaboration. Pour réaliser de telles chaînes, on prend un dérivé d'un diacide et une diamine dont l'un contient un oligomère hydrosoluble, de préférence du polyéthylène glycol, et on fait réagir l'un avec l'autre par étapes sur un support. Ces chaînes permettent ensuite de modifier chimiquement des macromolécules cibles et notamment des polypeptides biologiquement essentiels.

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