Polyamide modulators of cox2 transcription

Details Polyamide modulators of cox2 transcription Polyamide modulators of cox2 transcription

C - Chemistry, Metallurgy

12

N

C12N 5/02 (2006.01) A61K 31/4025 (2006.01) A61K 31/4178 (2006.01) C07D 207/30 (2006.01) C07D 231/02 (2006.01) C07D 403/02 (2006.01) C07D 403/14 (2006.01) C07K 14/575 (2006.01) C12N 15/63 (2006.01)

Patent

CA 2466391

Processes and compositions are provided for regulating COX2 gene expression in a cell. The process includes selecting a polyamide composition comprising N- methyl pyrrole (Py) and N-methyl imidazole (Im) to provide specific binding to DNA at a COX2 gene target site in a cell. The polyamide is then combined with the cell containing the COX2 gene, wherein the polyamide binds to the COX2 gene promoter target site and regulates transcription of the COX2 gene.

La présente invention concerne des procédés et des compositions pour réguler l'expression génique de la COX2 dans une cellule. Les procédés consistent à sélectionner une composition polyamide comprenant du N-méthyl pyrrole (Py) et du N-méthyl imidazole (Im), afin de fournir une liaison spécifique à un ADN au niveau d'un site cible du gène de la COX2 dans une cellule. Le polyamide est ensuite combiné avec la cellule contenant le gène de la COX2, il se lie alors au niveau du site promoteur cible du gène de la COX2 et régule la transcription du gène de la COX2.

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