C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 235/08 (2006.01) A61K 9/127 (2006.01) C07C 217/08 (2006.01) C07C 219/06 (2006.01) C07C 247/04 (2006.01) C07F 9/10 (2006.01) C08G 69/10 (2006.01)
Patent
CA 2315695
The present invention relates to new polyamide oligomers. These oligomers can be conjugated to lipids, nucleic acids, peptides, proteins, etc. The oligomer- lipid conjugates can be used to form liposomes, virusomes, micelles, etc., optionally containing drugs or biological agents. The polyamide oligomers are heterobifunctional allowing the attachment of other suitable ligand compounds (e.g., a targeting moiety). In addition, methods of use for the liposomes, virusomes, micelles, etc., are provided.
L'invention concerne de nouveaux oligomères polyamidiques qui peuvent se conjuguer avec des lipides, des acides nucléiques, des peptides, des protéines, etc. Les conjugués oligomère-lipide peuvent être utilisés pour former des liposomes, des virusomes, des micelles, etc., contenant éventuellement des médicaments ou des agents biologiques. Ces oligomères polyamidiques sont hétéro-bifonctionnels, ce qui permet la fixation d'autres composés ligands appropriés (p. ex. un fragment de ciblage). L'invention concerne également les procédés d'utilisation des liposomes, des virusomes, des micelles, etc.
Fetherstonhaugh & Co.
Inex Pharmaceuticals Corporation
Tekmira Pharmaceuticals Corporation
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