C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 211/27 (2006.01) C07C 211/36 (2006.01) C07D 211/26 (2006.01) C07D 213/38 (2006.01) C07D 233/54 (2006.01) C07D 277/04 (2006.01)
Patent
CA 2555862
Novel polyamines, their synthesis and use in pharmacological, cosmetic or agricultural applications are provided. The polyamines induce antizyme production which in turn down regulates both the production of polyamines by ornithine decarboxylase (ODC) and the transport of polyamines by its corresponding polyamine transporter. These compounds will preferably enter the cell independent of the polyamine transporter. As drugs, these compounds are used to treat any disease associated with cellular proliferation including but not limited to cancer.
La présente invention concerne de nouvelles polyamines, leur synthèse et leur utilisation dans des applications pharmacologiques, cosmétiques ou agricoles. Les polyamines induisent la production d'anti-enzymes qui produit à son tour une sous-régulation à la fois de la production de polyamines par l'ornithine décarboxylase (ODC) et le transport des polyamines par leur transporteur de polyamine correspondant. Ces composés pénètrent dans la cellule de préférence indépendamment du transporteur de polyamine. En tant que médicaments, ces composés sont utilisés pour traiter tout trouble associé à la prolifération cellulaire, comprenant, entre autre, le cancer.
Burns Mark R.
Graminski Gerard F.
Mediquest Therapeutics Inc.
Moffat & Co.
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