C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 211/14 (2006.01) A61K 31/132 (2006.01) A61K 31/133 (2006.01) A61K 31/145 (2006.01) C07C 211/22 (2006.01) C07C 215/18 (2006.01) C07C 215/24 (2006.01) C07C 323/25 (2006.01) C07C 323/27 (2006.01)
Patent
CA 2475349
The invention provides novel polyamine compounds and pharmaceutical compositions for administration in conjunction with cancer chemotherapy or radiation therapy. The compounds are administered locally to provide protection against the adverse side-effects of chemotherapy or radiation therapy, such as alopecia, mucositis and dermatitis. Pharmaceutical preparations comprising one or more chemoprotective polyamines formulated for topical or local delivery to epithelial or mucosal cells are disclosed. Methods of administering the pharmaceutical preparations are also disclosed.
L'invention concerne des nouveaux composés de polyamine et des compositions pharmaceutiques destinés à être administrés conjointement avec une chimiothérapie ou une radiothérapie anticancéreuse. Lesdits composés sont administrés localement afin d'assurer une protection contre les effets indésirables provoqués par la chimiothérapie et la radiothérapie, de type alopécie, mucosite et dermatite. L'invention concerne également des préparations pharmaceutiques comprenant une ou plusieurs polyamines chimioprotectrices formulées à des fins d'administration topique ou locale sur des cellules épithéliales ou des cellules de muqueuses. L'invention concerne en outre des procédés d'administration desdites préparations pharmaceutiques.
Copp Richard R.
Fahl Kathleen L.
Fahl William E.
Ochsner Cynthia E.
Peebles Daniel D.
Bereskin & Parr
Wisconsin Alumni Research Foundation
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