Polyamine derivatives as radioprotective agents

C - Chemistry – Metallurgy – 07 – C

Patent

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C07C 211/14 (2006.01) A61K 31/13 (2006.01) A61K 31/785 (2006.01) C07C 211/27 (2006.01) C07C 211/43 (2006.01) C07C 211/48 (2006.01) C07C 211/58 (2006.01)

Patent

CA 2154663

The present invention relates to polyamine derivatives of the formula RHN-(CH2)m-NH-(CH2)n-NHR wherein m is an integer from 2 to 4, n is an integer from 3 to 10 and R is C2-C6 alkyl or -(CH2)p-Ar wherein Ar is phenyl or naphthyl and p is an integer from 0 to 2; and the pharmaceutically acceptable addition salts thereof which are useful as radioprotective agents. It relates also to the use of polyamines of the formula RHN-(CH2)m-NH-(CH2)n-NH-(CH2)m-NHR wherein m is an integer from 2 to 4, n is an integer from 3 to 10 and R is C2-C6 alkyl or -(CH2)p-Ar wherein Ar is phenyl or naphthyl and p is an integer from 0 to 2; and the pharmaceutically acceptable addition salts thereof as radioprotective agents.

La présente invention se rapporte à des dérivés de polyamine de la formule RHN-(CH2)m-NH-(CH2)n-NHR dans laquelle m est un nombre entier de 2 à 4, n est un nombre entier de 3 à 10 et R représente alkyle C2-C6 ou -(CH2)p-Ar où Ar représente phényle ou naphtyle et p est un nombre entier de 0 à 2; et les sels d'addition pharmaceutiquement acceptables de ceux-ci qui sont utiles comme agents radioprotecteurs. L'invention se rapporte également à l'utilisation de polyamines de la formule RHN-(CH2)m-NH-(CH2)n-NH-(CH2)m-NHR dans laquelle m est un nombre entier de 2 à 4, n est nombre entier de 3 à 10 et R représente alkyle C2-C6 ou -(CH2)p-Ar où Ar représente phényle ou naphtyle et p est un nombre entier de 0 à 2; et les sels d'addition pharmaceutiquement acceptables de ceux-ci utilisés comme agents radioprotecteurs.

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