Polyamine drug-resin complexes

Details Polyamine drug-resin complexes Polyamine drug-resin complexes

A - Human Necessities

61

K

A61K 47/48 (2006.01) A61K 47/02 (2006.01) A61K 47/30 (2006.01)

Patent

CA 2098200

2098200 9211038 PCTABS00014 Disclosed are oral pharmaceutical preparations which comprise a pharmacologically-active polyamine drug bound to a cation-exchange resin to provide a drug-resin complex having a drug content greater than one equivalent of amine per equivalent of cation-exchange capacity. The drug-resin complex is optionally coated with a water-permeable diffusion barrier coating that is insoluble in gastrointestinal fluids thereby providing a controllable release of drug under conditions encountered in the gastrointestinal tract.

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