Polyamines and polypeptides useful as antagonists of...

Details Polyamines and polypeptides useful as antagonists of... Polyamines and polypeptides useful as antagonists of...

C - Chemistry, Metallurgy

07

C

530/13, 167/240,

C07C 235/50 (2006.01) A01N 43/38 (2006.01) A01N 43/50 (2006.01) A61K 31/405 (2006.01) C07C 239/16 (2006.01) C07D 209/18 (2006.01) C07D 209/28 (2006.01) C07K 14/435 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2015505

This invention relates to certain polyamines and polypeptides found to be present in the venom of the Agelenopsis aperta spider. The polyamines of this invention and the salts thereof antagonize excitatory amino acid neurotransmitters, which neurotransmitters affect cells of various organisms and are useful in antagonizing said neurotransmitters, per se, in the treatment of excitatory amino acid neurotransmitter mediated diseases and conditions and in the control of invertebrate pests. The polypeptides of this invention and one of said polyamines and the salts thereof block calcium channels in cells of various organisms and are useful in blocking said calcium channels in cells, per se, in the treatment of calcium channel mediated diseases and conditions and in the control of invertebrate pests. This invention also relates to compositions comprising said polyamines, polypeptides and salts thereof;

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