A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/39 (2006.01) A61K 39/00 (2006.01) A61P 37/02 (2006.01)
Patent
CA 2269780
Mucosal adjuvants for vaccines are disclosed comprised of water-soluble polyanionic polymers which have anionic constitutional units obtained from acids such as acrylic acid, methacrylic acid, maleic acid, fumaric acid, ethylsulphonic acid, vinylsulphuric acid, vinylsulphonic acid, styrenesulphonic acid, vinylphenylsulphuric acid, 2- methacryloyloxyethane sulphonic acid, 3-methacryloyloxy-2-hydroxypropanesulphonic acid, 3-methacryl amido-3- methylbutanoic acid, acrylamidomethylpropanesulphonic acid, vinylphosphoric acid, 4-vinylbenzoic acid, 3-vinyl oxypropane-1-sulphonic acid, N-vinylsuccinimidic acid, and salts of the foregoing. The polyanionic polymers may further have hydrophobic constitutional repeating units, such as alkylesters, cycloalkylesters, hydroxyalkylesters, ethers, glycols, aromatic groups and salts thereof. Also disclosed herein are use of the polyanionic polymers of the present invention for the induction or enhancement of mucosal immune responses, as well as nonparenteral vaccines containing the polyanionic polymer of the present invention.
On décrit des adjuvants des muqueuses destinés à des vaccins et comprenant des polymères polyanioniques hydrosolubles possédant des unités constitutionnelles anioniques obtenues à partir d'acides tels que l'acide acrylique, l'acide méthacrylique, l'acide maléique, l'acide fumarique, l'acide éthylsulfonique, l'acide vinylsulfurique, l'acide vinylsulfonique, l'acide styrènesulfonique, l'acide vinylphénylsulfurique, l'acide 2-méthacryloyloxyéthane sulfonique, l'acide 3-méthacryloyloxy-2-hydroxypropanesulfonique, l'acide 3-méthacryl-amido-3-méthylbutanoïque, l'acide acrylamidométhylpropanesulfonique, l'acide vinylphosphorique, l'acide 4-vinylbenzoïque, l'acide 3-vinyl-oxypropane-1-sulfonique, l'acide N-vinylsuccinimidique ainsi que des sels de ceux-ci. Ces polymères polyanioniques peuvent en outre posséder des motifs répétitifs constitutionnels et hydrophobes, tels que des alkylesters, des cycloalkylesters, des hydroxyalkylesters, des éthers, des glycols, des groupes aromatiques et des sels de ceux-ci. L'invention concerne également l'utilisation des polymères polyanioniques aux fins d'induction ou d'accroissement de réponses immunes des muqueuses, de même qu'en tant que vaccins non parentéraux contenant le polymère polyanionique de l'invention.
Dimminaco Ag/s.a./ltd.
Pfizer Ag
Ridout & Maybee Llp
LandOfFree
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