Polyarginine-modified liposome having nuclear entry ability

Details Polyarginine-modified liposome having nuclear entry ability Polyarginine-modified liposome having nuclear entry ability

A - Human Necessities

61

K

A61K 47/42 (2006.01) A61K 9/127 (2006.01) A61K 31/70 (2006.01) A61K 31/7048 (2006.01) A61K 38/00 (2006.01) C07K 7/00 (2006.01) C12N 15/88 (2006.01)

Patent

CA 2540917

It is intended to provide a liposome capable of transferring into a cell and transferring into a nucleus. To achieve this object, a liposome having a peptide containing plural consecutive arginine residues on its surface, more specifically speaking, the above liposome in which the peptide is modified with a hydrophobic group or a hydrophobic compound, the hydrophobic group or the hydrophobic compound is inserted into a lipid double layer and the peptide is exposed from the lipid double layer is provided.

L'invention concerne un liposome pouvant être transféré dans une cellule et dans un noyau. Pour ce faire, un liposome possédant un peptide contenant plusieurs restes d'arginine consécutifs sur sa surface, plus spécifiquement le liposomne dans lequel le peptide est modifié avec un groupe ou un composé hydrophobe, le composé ou le groupe est inséré dans une double couche lipidique et le peptide est exposé depuis la double couche lipidique.

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