C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
C07F 9/547 (2006.01) A61K 49/04 (2006.01) A61K 49/06 (2006.01) A61K 51/00 (2006.01) A61K 51/04 (2006.01) C07B 59/00 (2006.01) C07D 255/02 (2006.01) C07D 257/02 (2006.01) C07F 9/6515 (2006.01) C07F 9/6524 (2006.01)
Patent
CA 2140557
The present invention relates to a new polyazamacrocyclic compound or a salt thereof and its uses as a tissue specific chel- ator. The compound has formula (I), where x is 2, 3 or a combination of p 2(s) and q 3(s) where p + q = y; y is 3 or 4; R is (CH2)zP(=O)OR1OR2; R1 is H or CH3; R2 is CnH1+2n; n is 4 to 6; z is 1 to 3. In one important embodiment, this com- pound may be complexed with a metal to be a plyazamacrocyclic compound-metal complex having formula (II), where r is 2 or 3; and M is a metal ion, including a lanthanide, a heavy metal, or a radionuclide metal.
Kiefer Garry E.
Sherry Allan Dean
Bereskin & Parr
The Board Of Regents Of The University Of Texas System
The Dow Chemical Company
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