Polybasic bacterial efflux pump inhibitors and therapeutic...

Details Polybasic bacterial efflux pump inhibitors and therapeutic... Polybasic bacterial efflux pump inhibitors and therapeutic...

C - Chemistry, Metallurgy

07

K

C07K 5/06 (2006.01) A61K 38/05 (2006.01) A61P 31/04 (2006.01)

Patent

CA 2686994

Disclosed are compounds having polybasic functionalities. The compounds inhibit bacterial efflux pump inhibitors and are used in combination with an anti-bacterial agent to treat or prevent bacterial infections. These combinations can be effective against bacterial infections that have developed resistance to anti-bacterial agents through an efflux pump mechanism.

L'invention concerne des composés présentant des fonctionnalités polybasiques. Ces composés sont des inhibiteurs de pompes à efflux bactériennes et sont utilisés en combinaison avec un agent antibactérien pour traiter ou prévenir des infections bactériennes. Ces combinaisons peuvent être efficaces contre les infections bactériennes ayant développé une résistance contre des agents antibactériens par mise en oeuvre d'un mécanisme de pompe à efflux.

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