C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/00 (2006.01) A01N 37/18 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) A61K 38/16 (2006.01) A61K 47/48 (2006.01) A61P 5/20 (2006.01) A61P 7/00 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 19/00 (2006.01) C07K 14/16 (2006.01) C07K 14/705 (2006.01)
Patent
CA 2669914
The present invention provides methods and kits for treating hyperparathyroidism, bone disease and/or hypercalcemic disorders. In particular, methods for lowering serum PTH and serum calcium using polycationic calcium modulator peptides are provided. The calcium modulator peptides can be used to treat subjects having, for example: primary, secondary or tertiary hyperparathyroidism; hypercalcemia of malignancy; metastatic bone disease; or osteoporosis.
L'invention concerne des procédés et des kits de traitement de l'hyperparathyroïdie, de la maladie des os et/ou des troubles de l'hypercalcémie. En particulier, des procédés pour faire baisser le PTH sérique et le calcium sérique en utilisant des peptides modulateurs de calcium polycationique. Les peptides modulateurs de calcium peuvent être utilisés pour traiter des sujets atteints, par exemple, de : l'hyperparathyroïdie primaire, secondaire ou tertiaire; l'hypercalcémie maligne; la maladie des os métastatique; ou l'ostéoporose.
Bell Gregory
Karim Felix
Walter Sarah
Fetherstonhaugh & Co.
Kai Pharmaceuticals Inc.
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