C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 233/05 (2006.01) A61K 31/165 (2006.01) A61K 31/17 (2006.01) C07C 275/00 (2006.01)
Patent
CA 2570248
Aspects of the present invention relate to compounds and methods useful in modulating angiogenesis and methods of treating or preventing diseases associated with angiogenesis by administering a polycationic compound. The present invention relates to methods of use and compositions for inhibiting angiogenesis-mediated disorders in mammals including animals and humans. Additionally, this invention relates to the combined use of polycations with other anti-angiogenesis agents for the treatment of different angiogenesis- mediated disorders. Additionally, those polycationic compounds can be used with various anti-inflammatory and cytotoxic agents as well as with radio- therapeutic agents in cancer patients to prevent and treat tumor growth and metastasis.
Certains aspects de l'invention concerne des composés et des procédés utilisés dans la modulation de l'angiogenèse et des procédés pour traiter ou prévenir des maladies associées à l'angiogenèse, comprenant l'administration d'un composé polycationique. L'invention concerne des procédés d'utilisation et des compositions pour inhiber les troubles liés à l'angiogenèse chez les mammifères notamment les humains et les animaux. De plus, l'invention a pour objet l'utilisation combinée de polycations avec des agents anti-angiogenèse destinés au traitement des différents troubles médiés par l'angiogenèse. De plus, lesdits composés polycationiques peuvent être utilisés avec de nombreux agents anti-inflammatoires et cytotoxiques, ainsi que des agents radiothérapeutiques chez des patients atteints de cancers, ce qui permet de prévenir et de traiter la croissance de la tumeur et les métastases.
Borden Ladner Gervais Llp
Polymedix Inc.
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