Polyclonal populations of bispecific molecules and methods...

A - Human Necessities – 61 – K

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A61K 39/40 (2006.01) C12N 5/078 (2010.01) A61K 39/395 (2006.01) A61K 39/42 (2006.01) A61K 47/48 (2006.01) C07K 16/00 (2006.01) C07K 16/10 (2006.01) C07K 16/28 (2006.01) C07K 16/46 (2006.01) C12N 15/00 (2006.01)

Patent

CA 2441057

The invention relates to a polyclonal population of bispecific molecules which comprises a plurality of different bispecific molecules, each comprising a first antigen recognition portion that binds a C3b-like receptor cross-linked to a different second antigen recognition portion that binds a pathogenic antigenic molecule such that the plurality of different bispecific molecules have different second antigen recognition portions with different recognition specificities, such as with recognition specificities directed to different epitopes and/or different variants of a pathogen and/or to different pathogens. The invention also relates to methods of producing such polyclonal population of bispecific molecules. The invention further relates to methods of using such polyclonal population of bispecific molecules for the clearance of pathogens from the circulatory system of a mammal.

L'invention concerne une population polyclonale de molécules bispécifiques qui contient une pluralité de molécules bispécifiques différentes, présentant chacune une première partie de reconnaissance de l'antigène qui se lie à un récepteur de type C3b réticulé à un second fragment de reconnaissance de l'antigène qui se lie à une molécule d'antigène pathogène, de sorte que la pluralité de molécules bispécifiques différentes présentent différentes secondes parties de reconnaissance de l'antigène caractérisées par des spécificités de reconnaissance différentes, notamment des spécificités de reconnaissance relatives aux différents épitopes, et/ou différentes variantes d'un agent pathogène, et/ou différents agents pathogènes. Par ailleurs, l'invention concerne des méthodes de production de cette population polyclonale de molécules bispécifiques. De plus, elle concerne des méthodes d'utilisation de cette population polyclonale de molécules bispécifiques dans l'élimination d'agents pathogènes du système circulatoire des mammifères.

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