A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/48 (2006.01) A61K 47/30 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2660842
The present invention is directed to compounds, compositions, and methods useful for delivering polynucleotides or other cell-impermeable molecules to mammalian cells. Described are polyconjugates systems that incorporate targeting, anti-opsonization, anti- aggregation, and transfection activities into small biocompatible in vivo delivery vehicles. The use of multiple reversible linkages connecting component parts provides for physiologically responsive activity modulation.
La présente invention concerne des composés, des compositions et des procédés utiles pour administrer des polynucléotides, ou autres molécules imperméables aux cellules, à des cellules de mammifère. L'invention concerne des systèmes polyconjugués qui incorporent des activités de ciblage, d'anti-opsonisation, d'anti-agrégation et de transfection dans de petits véhicules biocompatibles de distribution in vivo. L'utilisation de multiples liaisons réversibles reliant des parties constitutives assure une modulation d'activité physiologiquement sensible.
Blokhin Andrei
Hagstrom James E.
Herweijer Hans
Klein Jason
Lewis David L.
F. Hoffmann-La Roche Ag
Gowling Lafleur Henderson Llp
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