Polycyclic aryl and heteroaryl substituted 1,4-quinones...

Details Polycyclic aryl and heteroaryl substituted 1,4-quinones... Polycyclic aryl and heteroaryl substituted 1,4-quinones...

C - Chemistry, Metallurgy

07

C

C07C 237/18 (2006.01) A61K 31/165 (2006.01) A61P 9/10 (2006.01) C07C 257/18 (2006.01) C07D 295/13 (2006.01)

Patent

CA 2405684

The invention relates to polycyclic aryl and heteroaryl substituted 1,4- quinone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety of thrombotic conditions including coronary artery and cerebrovascular diseases.

L'invention concerne de nouvelles 1,4-quinones polycycliques substituées par aryle et hétéroaryle utiles en tant qu'inhibiteurs des sérine protéases jouant un rôle dans les réactions en cascade provoquant la coagulation, ainsi que des composés, des compositions et des procédés pour la thérapie anticoagulante mise en oeuvre pour traiter et prévenir toute une variété d'états thrombotiques comprenant les maladies des artères coronaires et les maladies cérébrovasculaires.

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