Polycyclic aryl and heteroaryl substituted 4-pyridones...

Details Polycyclic aryl and heteroaryl substituted 4-pyridones... Polycyclic aryl and heteroaryl substituted 4-pyridones...

C - Chemistry, Metallurgy

07

D

C07D 213/74 (2006.01) A61K 31/4412 (2006.01) A61P 7/00 (2006.01) A61P 9/00 (2006.01)

Patent

CA 2405306

The invention relates to polycyclic aryl and heteroaryl substituted 4-pyridone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety of thrombotic conditions including coronary artery and cerebrovascular diseases.

La présente invention concerne des composés polycycliques de pyridone 4-aryl et hétéroaryl qui sont utiles en tant qu'inhibiteurs des sérine protéases de la cascade de coagulation et des composés, des compositions et des procédés destinés à l'anticoagulothérapie utilisée pour traiter et prévenir divers états thrombotiques y compris les maladies des artères coronaires et les maladies cérébrovasculaires.

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