C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 309/38 (2006.01) A61K 31/351 (2006.01) A61P 7/02 (2006.01) C07D 309/40 (2006.01) C07D 405/12 (2006.01)
Patent
CA 2405561
The invention relates to polycyclic aryl and heteroaryl substituted 4-pyrone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety of thrombotic conditions including coronary artery and cerebrovascular diseases.
L'invention concerne des composés de 4-pyrones polycycliques à substitution aryle et hétéroaryle utiles comme inhibiteurs de sérine protéases de la cascade de coagulation, et elle concerne aussi des composés, des compositions et des procédés de thérapie anticaogulation pour le traitement et la prévention d'une série d'affections thrombotiques y compris la coronaropathie et les maladies cérébrovasculaires.
Koeller Kevin J.
Ma Chun C.
Neumann William L.
Rahman Hayat K.
South Michael S.
Pharmacia Corporation
Smart & Biggar
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