C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/04 (2006.01) A61K 31/4196 (2006.01) A61P 19/00 (2006.01) A61P 35/00 (2006.01) C07D 403/14 (2006.01) C07D 471/18 (2006.01) C07D 491/14 (2006.01)
Patent
CA 2704052
Polycyclic aryl and polycyclic heteroaryl substituted triazoles and pharmaceutical compositions containing the compounds are disclosed as being useful in inhibiting the activity of the receptor protein tyrosine kinase Axl. Methods of using the compounds in treating diseases or conditions associated with Axl catalytic activity are also disclosed.
L'invention porte sur des triazoles substitués par aryle polycyclique et hétéroaryle polycyclique et sur des compositions pharmaceutiques contenant les composés. Ces triazoles sont utiles pour inhiber l'activité du récepteur de la protéine tyrosine kinase Axl. L'invention porte sur des procédés d'utilisation des composés dans le traitement de maladies ou affections associées à une activité catalytique d'Axl.
Ding Pingyu
Goff Dane
Heckrodt Thilo
Holland Sacha
Litvak Joane
Gowling Lafleur Henderson Llp
Rigel Pharmaceuticals Inc.
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