C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/4745 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2461572
Novel polycyclic compounds of the formula [I] wherein R1, R2, R3, R4, R5, R6, R7, ring A, ring B, X, Y and Z are as defined in the claims and description as well as pharmaceutically acceptable salts thereof. The compounds have antitumor activity and useful for the treatment of tumor.
L'invention concerne de nouveaux composés polycycliques de formule (I) dans laquelle R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, R?6¿, R?7¿, le composé cyclique A, le composé cyclique B, X, Y et Z ont la signification mentionnée dans les revendications et la description, de même que leurs sels pharmaceutiquement acceptables. Ces composés présente une activité antitumorale et s'utilisent dans le traitement de tumeurs.
Aoyama Tsunehisa
Kawasaki Kenichi
Masubuchi Miyako
Ohtsuka Tatsuo
Sakata Kiyoaki
F. Hoffmann-La Roche Ag
Gowling Lafleur Henderson Llp
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