Polycyclic dianthraquinones as inhibitors of inflammatory...

A - Human Necessities – 61 – K

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A61K 31/122 (2006.01) A61P 25/28 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2659800

The present invention relates to the therapeutic use of polycyclic dianthraquinones including hypericin, helianthrones and helianthrone derivatives as inhibitors of the proinflammatory cytokine cascade mediated inflammatory conditions such as inflammatory bowel disease and cachexia. In addition the compositions can be used for prevention of development of inflammation, fibrosis and vasculopathy as a sequelae induced by irradiation treatment, and to the use thereof, as protective modes for the consequences of irradiation treatment in diseases such as cancers. The present invention can also be used to prevent or improve the inflammatory consequences of infections with viruses or bacteria and to prevent or treat neuroinflammatory disorders.

La présente invention concerne l'utilisation thérapeutique de dianthraquinones polycycliques comprenant l'hypericine, les hélianthrones et les dérivés d'hélianthrones comme inhibiteurs des conditions inflammatoires à médiation par la cascade de cytokines proinflammatoires, telles que la maladie intestinale inflammatoire et la cachexie. De plus, les compositions peuvent être utilisées pour la prévention du développement d'une inflammation, d'une fibrose et d'une vasculopathie constituant les séquelles d'un traitement par irradiation, et comme prévention des conséquences néfastes d'un traitement par irradiation dans les maladies telles que les cancers. La présente invention peut également être utilisée pour prévenir ou pour diminuer les conséquences inflammatoires d'infections par virus ou bactéries et pour prévenir ou traiter des troubles neuroinflammatoires.

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