Polycyclic ether antibiotics

Details Polycyclic ether antibiotics Polycyclic ether antibiotics

C - Chemistry, Metallurgy

07

H

195/87, 260/233.

C07H 17/04 (2006.01) A61K 31/70 (2006.01) C07H 19/01 (2006.01) C12P 19/44 (2006.01) C12P 19/60 (2006.01)

Patent

CA 1236414

ABSTRACT NEW POLYCYCLIC ETHER ANTIBIOTICS A new acidic polycyclic ether antibiotic UK-58,852 has the formula: Image wherein R and R1 are both hydrogen, and can be prepared by the submerged aerobic propogation in aqueous nutrient media of Actinomadura sp. ATCC 39697. The antibiotic and its cationic salts are active against a variety of microorganisms and are effective in controlling coccidiosis, enteritis, swine dysentery and theileriosis as well as being effective in promotion of growth and/or improving efficiency of feed utilisatiion in swine and ruminants. Two minor components,wherein R is H and R1 is CH3 and wherein R and R1 are both CH3,have also been isolated from the fermentation.

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