Polycyclic indazole derivatives that are erk inhibitors

Details Polycyclic indazole derivatives that are erk inhibitors Polycyclic indazole derivatives that are erk inhibitors

C - Chemistry, Metallurgy

07

D

C07D 231/56 (2006.01) A61K 31/427 (2006.01) A61K 31/428 (2006.01) A61K 31/496 (2006.01) A61K 31/506 (2006.01) A61P 35/00 (2006.01) C07D 403/12 (2006.01) C07D 403/14 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2633023

Disclosed are the ERK inhibitors of formula 1.0 and the pharmaceutically acceptable salts and solvates thereof. Q is a piperidine or piperazine ring that can have a bridge or a fused ring. The piperidine ring can have a double bond in the ring. All other substitutents are as defined herein. Also disclosed are methods of treating cancer using the compounds of formula 1Ø

La présente invention concerne des inhibiteurs des kinases régulées par des signaux extracellulaires (ERK) de formule 1.0 et leurs sels et solvates pharmaceutiquement acceptables. Q est un cycle pipéridine ou pipérazine qui peut comporter un cycle fusionné ou un pont. Le cycle pipéridine peut comporter une double liaison. Tous les autres substituants sont tels que définis ici. L'invention concerne également des procédés de traitement du cancer à l'aide des composés de formule 1Ø

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