Polycyclic nitrile compounds and pharmaceutical compositions...

Details Polycyclic nitrile compounds and pharmaceutical compositions... Polycyclic nitrile compounds and pharmaceutical compositions...

C - Chemistry, Metallurgy

07

D

167/233, 260/298

C07D 487/08 (2006.01) A61K 31/40 (2006.01)

Patent

CA 2032124

ABSTRACT This invention provides compounds-of general formula I: A-R (I) wherein A is 4-azapentacyclo (5.4.1.02'6 .03'10 .05'9 .08'11] dodecane optionally substituted with one or more substituents, comprising, a cyano, an hydroxy, an amino, alkyl, aryl, nitro or keto group, and R is a substituent on the aza nitrogen, composing hydrogen or an unsubstituted or substituted aromatic or an unbranched or branched alkyl group, the alkyl group optionally having as a substituent an aryl or hydroxy group or a halogen; and acid addition salts of such compounds. This invention also provides a process for preparing such compounds; and a calcium antagonist and/or a cardiac agent or composition containing an effective amount of at least one of such compounds.

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