C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 493/08 (2006.01) A61K 31/52 (2006.01) A61P 9/00 (2006.01) A61P 25/28 (2006.01) C07D 307/00 (2006.01) C07D 311/00 (2006.01) C07D 453/02 (2006.01) C07D 473/06 (2006.01) C07D 519/00 (2006.01)
Patent
CA 2390496
The invention is based on the discovery that compounds of Formula (I) are unexpectedly highly potent and selective inhibitors of the adenosine A1 receptor. Adenosine A1 antagonists can be useful in the prevention and/or treatment of numerous diseases, including cardiac and circulatory disorders, degenerative disorders of the central nervous system, respiratory disorders, and many diseases for which diuretic treatment is suitable. In one embodiment, the invention features a compound of formula (I).
La présente invention concerne des composés de formule (I), qui sont, de manière inattendue, des inhibiteurs sélectifs et très puissants du récepteur d'adénosine A¿1?. Des antagonistes de l'adénosine A¿1? peuvent être utiles dans la prévention et/ou le traitement de nombreuses maladies, y compris de troubles cardiaques et circulatoires, de troubles dégénératifs du système nerveux central, de troubles respiratoires, et dans de nombreuses maladies pour lesquelles un traitement diurétique convient. Dans une réalisation, l'invention concerne un composé de formule (I).
Chang He Xi
Dowling James E.
Ensinger Carol L.
Kiesman William F.
Kumaravel Gnanasambandam
Biogen Inc.
Biogen Idec Ma Inc.
Smart & Biggar
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