Polyelectrolyte complex for imparting antimicrobial...

A - Human Necessities – 61 – L

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A61L 2/16 (2006.01) A61L 2/18 (2006.01) A61L 2/232 (2006.01)

Patent

CA 2731072

Anionic polyelectrolytes are used as binding agents to reduce the solubility of cationic antimicrobial polyelec-trolytes. Ionic attraction between the anionic stabilizing polyelectrolytes and the antimicrobial cationic polyelectrolytes results in formation of a polyelectrolyte complex (PEC). A treatment liquid comprising a stable colloid, suspension, dispersion, solution, coacervate, or emulsion of the PEC in an aqueous carrier is used to treat an absorbent substrate, thus coating, infiltrating, or infusing the PEC onto or into the substrate. Subsequent drying results in a modified substrate which is bound to the substrate and is significantly less prone, relative to either of the component polyelectrolytes, to being washed, leached, leaked, extracted, or mi-grated from the substrate during use, or when exposed to aqueous fluids or solvents. The modified substrate can be further treated with ethylene oxide which enahnces its antimicrobial efficacy, its biocompatibility, and its utility in wound dressings, medical de-vices, clothing, etc.

L'invention concerne des poly-électrolytes anioniques utilisés en tant qu'agents de liaison pour réduire la solubilité de poly-électrolytes antimicrobiens cationiques. Lattraction ionique entre les poly-électrolytes de stabilisation anioniques et les poly-électrolytes cationiques antimicrobiens a pour résultat la formation d'un complexe électrolytique (PEC). Un liquide de traitement comportant un colloïde stable, une suspension, une dispersion, une solution, un coacervat ou une émulsion du PEC dans un support aqueux, est utilisé pour traiter un support absorbant, recouvrant, infiltrant ou infusant ainsi le PEC sur ou dans le substrat. Un séchage ultérieur a pour résultat un substrat modifié qui est lié au substrat et qui est sensiblement moins sujet, par rapport aux poly-électrolytes constitutifs, d'être lavé, blanchi, de fuir, d'être extrait ou de migrer depuis le substrat en utilisation, ou lors d'une exposition à des fluides ou à des solvants aqueux. Le substrat modifié peut en outre être traité avec de l'oxyde d'éthylène qui améliore son efficacité antimicrobienne, sa biocompatibilité, et son utilité dans des pansements, des dispositifs médicaux, des vêtements, etc.

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