Polyene compounds

Details Polyene compounds Polyene compounds

C - Chemistry, Metallurgy

07

C

260/552, 260/515

C07C 57/42 (2006.01) C07C 57/50 (2006.01) C07C 59/74 (2006.01) C07C 69/618 (2006.01) C07C 233/09 (2006.01)

Patent

CA 1276032

Abstract Compounds of the formula Image I wherein R1 is a group or the formula Image (a) (b) or Image (c), R2 is hydroxy, lower-alkoxy, amino, mono- -(lower-alkyl)amino or di-(lower-alkyl)- amino, R3 is lower-alkyl or halogen, R4 is lower-alkyl, R5 is lower-alkoxy, R6 is hydrogen or lower-alkyl and R7 is lower-alkyl or halogen, and pharmaceutically acceptable salts of the carboxylic acids of formula I can be used for the treatment of neo- plasms and dermatoses. The compounds of formula I can be obtained by forming the side-chain from corresponding cyclic and aliphatic components by means of a Wittig or Horner reaction.

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