Polyene polyketides, processes for their production and...

Details Polyene polyketides, processes for their production and... Polyene polyketides, processes for their production and...

C - Chemistry, Metallurgy

07

D

C07D 317/12 (2006.01) A61K 31/197 (2006.01) A61K 31/336 (2006.01) A61K 31/341 (2006.01) A61P 31/10 (2006.01) A61P 35/00 (2006.01) C07C 215/24 (2006.01) C07C 237/12 (2006.01) C07C 237/18 (2006.01) C07C 279/08 (2006.01) C07C 279/22 (2006.01) C07C 305/14 (2006.01) C07D 213/81 (2006.01) C12P 1/04 (2006.01) C12P 7/40 (2006.01) C12P 7/42 (2006.01) C12P 11/00 (2006.01) C12P 13/00 (2006.01) C12P 17/06 (2006.01) C12P 17/10 (2006.01) C12P 19/44 (2006.01)

Patent

CA 2467249

This invention relates to a novel class of linear polyene polyketides, their pharmaceutically acceptable salts and derivatives, and to methods for their production. The compounds may be obtained by cultivation of Streptomyces melanosporafaciens species and isolation of the polyene polyketide, followed by optional chemical production of the isolated polyene polyketide. The compounds may also be produced by other known bacteria. The invention further includes the use of these compounds as inhibitors of fungal cell growth and inhibitors of cancer cell growth. Finally, the invention encompasses pharmaceutical compositions comprising these novel polyketide compounds, or their pharmaceutically acceptable salts or derivatives thereof.

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