C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/62 (2006.01) A61K 31/70 (2006.01) A61K 39/00 (2006.01) A61K 39/295 (2006.01) A61K 48/00 (2006.01) C07K 4/02 (2006.01) C07K 4/04 (2006.01) C07K 14/00 (2006.01) C07K 19/00 (2006.01) C12N 15/31 (2006.01) C12N 15/86 (2006.01)
Patent
CA 2195642
The present invention relates to a recombinant polyepitope cytotoxic T lymphocyte vaccine. The vaccine comprises at least one recombinant protein including a plurality of cytotoxic T lymphocyte epitopes from one or more pathogens, wherein the at least one recombinant protein is substantially free of sequences naturally found to flank the cytotoxic T lymphocyte epitopes. In addition the present invention also provides a polynucleotide including at least one sequence encoding a plurality of cytotoxic T lymphocyte epitopes from one or more pathogens.
L'invention concerne un vaccin à base de lymphocytes T cytotoxiques polyépitopiques de recombinaison. Le vaccin est constitué d'au moins une protéine de recombinaison comprenant une pluralité d'épitopes de lymphocytes T cytotoxiques d'un ou plusieurs germes pathogènes, la ou lesdites protéines de recombinaison étant sensiblement exemptes des séquences qui encadrent naturellement les épitopes de lymphocytes T cytotoxiques. L'invention porte également sur un polynucléotide comprenant au moins une séquence codant une pluralité d'épitopes de lymphocytes T cytotoxiques d'un ou plusieurs germes pathogènes.
Burrows Scott Renton
Coupar Barbara Elizabeth Howieson
Khanna Rajiv
Moss Denis James
Suhrbier Andreas
Biotech Australia Pty Limited
Commonwealth Scientific And Industrial Research Organisation
Csl Limited
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
The Council Of The Queensland Institute Of Medical Research
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