C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 17/08 (2006.01) A61K 38/26 (2006.01) A61K 47/48 (2006.01) A61P 1/00 (2006.01) A61P 3/04 (2006.01) A61P 3/10 (2006.01) C07K 14/605 (2006.01)
Patent
CA 2518336
The invention provides GLP-1 compounds coupled to at least one polyethylene glycol molecule or derivative thereof, resulting in a biologically active peptide with an extended half-life and a slower clearance when compared to that of unPEGylated peptide. These PEGylated GLP-1 compounds and compositions are useful in treating diabetes, obesity, irritable bowel syndrome and other conditions that would be benefited by lowering plasma glucose, inhibiting gastric and/or intestinal motility and inhibiting gastric and/or intestinal emptying, or inhibiting food intake.
L'invention concerne des composés GLP-1 couplés à au moins une molécule d'éthylène glycol ou à un dérivé d'une telle molécule, le résultat étant un peptide biologiquement actif ayant une demi-vie accrue et une clairance plus lente qu'un peptide PEGylaté. Ces composés et compositions GLP-1 PEGylatés1 sont utiles pour le traitement du diabète, de l'obésité, du syndrome du colon irritable et autres pathologies pour lesquels un abaissement du glucose plasmatique, l'inhibition de la motilité gastrique et/ou intestinale, l'inhibition de la vidange gastrique et/ou intestinale ou l'inhibition de la prise de nourriture sont bénéfiques.
Dimarchi Richard Dennis
Glaesner Wolfgang
Millican Rohn Lee Junior
Vick Andrew Mark
Zhang Lianshan
Eli Lilly And Company
Gowling Lafleur Henderson Llp
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